Search results for "Ressonància magnètica"
showing 10 items of 16 documents
Urinary 1H Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a…
2017
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (≤ 4 g/day of pulse intake) and habitual pulse consumers (≥ 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through…
NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates
2016
Folding of G-protein coupled receptors (GPCRs) according to the two-stage model (Popot, J. L., and Engelman, D. M. (1990) Biochemistry 29, 4031-4037) is postulated to proceed in 2 steps: partitioning of the polypeptide into the membrane followed by diffusion until native contacts are formed. Herein we investigate conformational preferences of fragments of the yeast Ste2p receptor using NMR. Constructs comprising the first, the first two, and the first three transmembrane (TM) segments, as well as a construct comprising TM1-TM2 covalently linked to TM7 were examined. We observed that the isolated TM1 does not form a stable helix nor does it integrate well into the micelle. TM1 is significant…
Distribution and genotype-phenotype correlation of GDAP1 mutations in Spain
2017
AbstractMutations in the GDAP1 gene can cause Charcot-Marie-Tooth disease. These mutations are quite rare in most Western countries but not so in certain regions of Spain or other Mediterranean countries. This cross-sectional retrospective multicenter study analyzed the clinical and genetic characteristics of patients with GDAP1 mutations across Spain. 99 patients were identified, which were distributed across most of Spain, but especially in the Northwest and Mediterranean regions. The most common genotypes were p.R120W (in 81% of patients with autosomal dominant inheritance) and p.Q163X (in 73% of autosomal recessive patients). Patients with recessively inherited mutations had a more seve…
Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study
2014
[Abstract.] Music is a highly complex and versatile stimulus for the brain that engages many temporal, frontal, parietal, cerebellar, and subcortical areas involved in auditory, cognitive, emotional, and motor processing. Regular musical activities have been shown to effectively enhance the structure and function of many brain areas, making music a potential tool also in neuro- logical rehabilitation. In our previous randomized controlled study, we found that listening to music on a daily basis can improve cognitive recovery and improve mood after an acute mid- dle cerebral artery stroke. Extending this study, a voxel-based morphometry (VBM) analysis utilizing cost function masking was perf…
A Refractive Index Sensor Based on the Resonant Coupling to Cladding Modes in a Fiber Loop
2013
We report an easy-to-build, compact, and low-cost optical fiber refractive index sensor. It consists of a single fiber loop whose transmission spectra exhibit a series of notches produced by the resonant coupling between the fundamental mode and the cladding modes in a uniformly bent fiber. The wavelength of the notches, distributed in a wavelength span from 1,400 to 1,700 nm, can be tuned by adjusting the diameter of the fiber loop and are sensitive to refractive index changes of the external medium. Sensitivities of 170 and 800 nm per refractive index unit for water solutions and for the refractive index interval 1.40-1.442, respectively, are demonstrated. We estimate a long range resolut…
Light induced electron spin resonance in a-Ge:H
1999
We report the observation of light-induced electron spin resonance (LESR) in amorphous hydrogenated germanium. Two new lines with zero crossings near g=2.01 and g=2.03 were detected and ascribed to electrons and holes in the conduction- and valence-band-tail states, respectively. The ratio between the LESR spin densities of both lines is approximately one, suggesting the absence of spin pairing, charge defect creation, or LESR of dangling bonds. The growth and decay spectra exhibit dispersive behavior with a dispersion parameter ∼0.5. The decay spectrum is best fit assuming bimolecular recombination. The LESR spin density depends weakly on the photogeneration rate as a sublinear power law.
Optimización de la secuencia de difusión en RM 3T con modelo multifactorial IVIM en el estudio de la próstata
2017
Introducción El cáncer de próstata (caP) supone la neoplasia maligna más frecuentemente diagnosticada en el varón. Este tumor ha registrado un progresivo aumento de su incidencia en los últimos años, fundamentalmente por el amplio uso de la determinación del PSA (antígeno prostático específico en suero), el aumento de la esperanza de vida, y la existencia de más y mejores métodos diagnósticos. A pesar del aumento de su incidencia, actualmente muchos pacientes se consiguen diagnosticar en estadios iniciales de la enfermedad cuando el tumor está localizado y se pueden beneficiar de un aumento en las posibilidades de curación. Además, los avances en los tratamientos ofrecen nuevas opciones ter…
Kr-96(36)60-Low-Z Boundary of the Island of Deformation at N=60
2017
Prompt.-ray spectroscopy of the neutron-rich Kr-96, produced in transfer-and fusion-induced fission reactions, has been performed using the combination of the Advanced Gamma Tracking Array and the VAMOS + +spectrometer. A second excited state, assigned to J pi = 4(+), is observed for the first time, and a previously reported level energy of the first 2+ excited state is confirmed. The measured energy ratio R-4/2 = E(4(+))/E(2(+)) = 2.12(1) indicates that this nucleus does not show a well-developed collectivity contrary to that seen in heavier N = 60 isotones. This new measurement highlights an abrupt transition of the degree of collectivity as a function of the proton number at Z = 36, of s…
Metabolomic Pattern Analysis after Mediterranean Diet Intervention in a Nondiabetic Population: A 1- and 3-Year Follow-up in the PREDIMED Study
2014
The Mediterranean diet (MD) is considered a dietary pattern with beneficial effects on human health. The aim of this study was to assess the effect of an MD on urinary metabolome by comparing subjects at 1 and 3 years of follow-up, after an MD supplemented with either extra-virgin olive oil (MD + EVOO) or nuts (MD + Nuts), to those on advice to follow a control low-fat diet (LFD). Ninety-eight nondiabetic volunteers were evaluated, using metabolomic approaches, corresponding to MD + EVOO (n = 41), MD + Nuts (n = 27), or LFD (n = 30) groups. The (1)H NMR urinary profiles were examined at baseline and after 1 and 3 years of follow-up. Multivariate data analysis (OSC-PLS-DA and HCA) methods we…
Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron : The Myocardial- Trial
2020
Background Intravenous ferric carboxymaltose ( FCM ) improves symptoms, functional capacity, and quality of life in heart failure and iron deficiency. The mechanisms underlying these effects are not fully understood. The aim of this study was to examine changes in myocardial iron content after FCM administration in patients with heart failure and iron deficiency using cardiac magnetic resonance. Methods and Results Fifty‐three stable heart failure and iron deficiency patients were randomly assigned 1:1 to receive intravenous FCM or placebo in a multicenter, double‐blind study. T2* and T1 mapping cardiac magnetic resonance sequences, noninvasive surrogates of intramyocardial iron, were eval…